Publications
2025
Kagalwala ZB, Chhipa MA, Kianfard Z, Karam E, Magalage SP, Sabatinos SA. Checkpoint-Dependent Sensitivities to Nucleoside Analogues Uncover Specific Patterns of Genomic Instability. Curr Issues Mol Biol. 2025 Sep 12;47(9):756. doi: 10.3390/cimb47090756. PMID: 41020877; PMCID: PMC12468036.
Cheng K, Aliar K, Manshaei R, Forsburg SL, Mazalek A, Sabatinos SA. Modelling DNA replication fork stability and collapse using chromatin fiber analysis and the R-ODD-BLOBS program. bioRxiv [Preprint]. 2025 Nov 2:2024.11.01.621594. doi: 10.1101/2024.11.01.621594. PMID: 41279996; PMCID: PMC12636476.
Yao XQ, Sabatinos SA, Da Silva E, Taggar A, Ha D, Khan R, Karshafian R, Gräfe J. Therapeutic enhancement effects using a lower energy 2.5 MV photon beam combined with gold nanoparticles on the BxPC-3 pancreatic cancer cell line,in vitro. Phys Med Biol. 2025 May 15;70(10). doi: 10.1088/1361-6560/add4b8. PMID: 40328291.
Samantha A Sanayhie, Victoria Da Pra, Nairy Khodabshakian, Essam Karam, Mohammed Aya Chhipa, Seerat Kang, Asiya Ahmed, Jeffrey Fillingham, Sarah A Sabatinos. Fission yeast histone chaperone Rtt106 regulates histone levels, prevents early division, and promotes genome stability. bioRxiv 2025.11.01.686071; doi: https://doi.org/10.1101/2025.11.01.686071
Karam, E., Sabatinos, S.A. (2025). Investigating Fission Yeast Mutagenesis Using Canavanine Sensitivity Assays. In: Petreaca, R.C. (eds) Schizosaccharomyces pombe. Methods in Molecular Biology, vol 2862. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-4168-2_14
Sanayhie, S.A., Sabatinos, S.A. (2025). Identifying Drug Sensitivities in Fission Yeast by Assessing Growth Kinetics. In: Petreaca, R.C. (eds) Schizosaccharomyces pombe. Methods in Molecular Biology, vol 2862. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-4168-2_23
Chhipa, M.A., Sanayhie, S.A., Sabatinos, S.A. (2025). Assessing Drug Sensitivity in Fission Yeast Using Half-Maximal Inhibitory Concentration (IC50) Assays. In: Petreaca, R.C. (eds) Schizosaccharomyces pombe. Methods in Molecular Biology, vol 2862. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-4168-2_17
2024
Kerenza Cheng, Kazeera Aliar, Roozbeh Manshaei, Ali Mazalek, Sarah A Sabatinos. bioRxiv 2024.11.01.621594; doi: https://doi.org/10.1101/2024.11.01.621594
2023
Manuel Lera-Ramírez, Jürg Bähler, Juan Mata, Kim Rutherford, Charles S Hoffman, Sarah Lambert, Snezhana Oliferenko, Sophie G Martin, Kathleen L Gould, Li-Lin Du, Sarah A Sabatinos, Susan L Forsburg, Olaf Nielsen, Paul Nurse, Valerie Wood, Revised fission yeast gene and allele nomenclature guidelines for machine readability, Genetics, Volume 225, Issue 3, November 2023, iyad143, https://doi.org/10.1093/genetics/iyad143
2022
Kianfard Z, Sabatinos SA. Keeping the strands together: Rad53 regulation of fork symmetry promotes replication stability. Bioessays. 2022 Sep;44(9):e2200141. doi: 10.1002/bies.202200141. Epub 2022 Aug 15. PMID: 35971183. invited review.
Roozbeh Manshaei, Uzair Mayat, Syeda Aniqa Imtiaz, Veronica Andric, Kazeera Aliar, Nour Abu Hantash, Kashaf Masood, Gabby Resch, Alexander Bakogeorge, Sarah Sabatinos, and Ali Mazalek. 2022. Tangible Chromatin: Tangible and Multi-surface Interactions for Exploring Datasets from High-Content Microscopy Experiments. Proc. ACM Hum.-Comput. Interact. 6, ISS, Article 558 (December 2022), 22 pages. https://doi.org/10.1145/3567711
Kianfard, Z., Cheung, K., Sabatinos, S.A. (2022). Cell Cycle Synchrony Methods for Fission Yeast, Schizosaccharomyces pombe. In: Wang, Z. (eds) Cell-Cycle Synchronization. Methods in Molecular Biology, vol 2579. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-2736-5_13
Kianfard, Z., Cheung, K., Rappaport, D., Magalage, S.P., Sabatinos, S.A. (2022). Detecting Cell Cycle Stage and Progression in Fission Yeast, Schizosaccharomyces pombe. In: Wang, Z. (eds) Cell-Cycle Synchronization. Methods in Molecular Biology, vol 2579. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-2736-5_18
2021
Sugiyama, M.G., Cui, H., Redka, D.S. et al. Multiscale interactome analysis coupled with off-target drug predictions reveals drug repurposing candidates for human coronavirus disease. Sci Rep 11, 23315 (2021). https://doi.org/10.1038/s41598-021-02432-7
2019
Campbell, L. G., Dufresne, J., & Sabatinos, S. A. (2019). Cannabinoid inheritance relies on complex genetic architecture. Cannabis and Cannabinoid Research, 5(1), 105–116. https://doi.org/10.1089/can.2018.0015
Boras, I., Nasser, R., Sabatinos, S. and Antonescu, C.N. (2019), Signaling by the Epidermal Growth Factor Receptor regulates DNA repair. The FASEB Journal, 33: 457.2-457.2. https://doi.org/10.1096/fasebj.2019.33.1_supplement.457.2
2018
Patel, P., Cheung, K., Kianfard, Z., & Sabatinos, S. A. (2018, December). Heat shock promotes replication stress survival. In MOLECULAR BIOLOGY OF THE CELL (Vol. 29, No. 26, pp. 189-190). 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA: AMER SOC CELL BIOLOGY.
Nora S Dannah, Syed Nabeel-Shah, Christoph F Kurat, Sarah A Sabatinos, Jeffrey Fillingham, Functional Analysis of Hif1 Histone Chaperone in Saccharomyces cerevisiae, G3 Genes|Genomes|Genetics, Volume 8, Issue 6, 1 June 2018, Pages 1993–2006, https://doi.org/10.1534/g3.118.200229
Sabatinos, S.A., Green, M.D. (2018). A Chromatin Fiber Analysis Pipeline to Model DNA Synthesis and Structures in Fission Yeast. In: Muzi-Falconi, M., Brown, G. (eds) Genome Instability. Methods in Molecular Biology, vol 1672. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7306-4_34
2017
Patel, P., Kianfard, Z., & Sabatinos, S. A. (2017, January). Mapping mechanisms of drug sensitivity and resistance: genetics and environment. In MOLECULAR BIOLOGY OF THE CELL (Vol. 28). 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA: AMER SOC CELL BIOLOGY.
2016
Patel, P. N., & Sabatinos, S. A. (2016, January). Pre-exposure to environmental stress alters survival under DNA replication instability. In MOLECULAR BIOLOGY OF THE CELL (Vol. 27). 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA: AMER SOC CELL BIOLOGY.
Sabatinos, S. A., Greens, M. D., & Forsburg, S. L. (2016, January). Defining phenotypic heterogeneity and predicting cell fate post-drug in fission yeast. In MOLECULAR BIOLOGY OF THE CELL (Vol. 27). 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA: AMER SOC CELL BIOLOGY.
Kianfard, Z., & Sabatinos, S. A. (2016, January). Studying the Genetic Requirements of Gemcitabine Resistance in Fission Yeast. In MOLECULAR BIOLOGY OF THE CELL (Vol. 27). 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA: AMER SOC CELL BIOLOGY.
2015
Replication stress in early S phase generates apparent micronuclei and chromosome rearrangement in fission yeast. Sarah A. Sabatinos, Nimna S. Ranatunga, Ji-Ping Yuan, Marc D. Green, and Susan L. ForsburgMolecular Biology of the Cell 2015 26:19, 3439-3450
Sabatinos SA, Forsburg SL. Managing Single-Stranded DNA during Replication Stress in Fission Yeast. Biomolecules. 2015; 5(3):2123-2139. https://doi.org/10.3390/biom5032123
Sabatinos, S. A., Ranatunga, N. S., Yuan, J., Green, M., & Forsburg, S. L. (2015, January). Early replication stress leads to abnormal mitosis and genome rearrangement. In MOLECULAR BIOLOGY OF THE CELL (Vol. 26). 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA: AMER SOC CELL BIOLOGY
Sabatinos, S.A., Forsburg, S.L. (2015). Measuring DNA Content by Flow Cytometry in Fission Yeast. In: Vengrova, S., Dalgaard, J. (eds) DNA Replication. Methods in Molecular Biology, vol 1300. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-2596-4_5
Green, M.D., Sabatinos, S.A., Forsburg, S.L. (2015). Microscopy Techniques to Examine DNA Replication in Fission Yeast. In: Vengrova, S., Dalgaard, J. (eds) DNA Replication. Methods in Molecular Biology, vol 1300. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-2596-4_2
2014
Y. -J. Chen, M. D. Green, S. A. Sabatinos, S. L. Forsburg, Chun-Nan Hsu and J. -Y. Peng, “Automatic phenotyping of multi-channel Schizosaccharomyces pombe images,” 2014 IEEE International Symposium on Bioelectronics and Bioinformatics (IEEE ISBB 2014), Chung Li, Taiwan, 2014, pp. 1-4, doi: 10.1109/ISBB.2014.6820935.
2013
Peng J-Y, Chen Y-J, Green MD, Sabatinos SA, Forsburg SL, Hsu C-N (2013) PombeX: Robust Cell Segmentation for Fission Yeast Transillumination Images. PLoS ONE 8(12): e81434. https://doi.org/10.1371/journal.pone.0081434
A., S., & L., S. (2013). Preserving the Replication Fork in Response to Nucleotide Starvation: Evading the Replication Fork Collapse Point. InTech. doi: 10.5772/51393
Sarah A Sabatinos, Tara L Mastro, Marc D Green, Susan L Forsburg, A Mammalian-Like DNA Damage Response of Fission Yeast to Nucleoside Analogs, Genetics, Volume 193, Issue 1, 1 January 2013, Pages 143–157, https://doi.org/10.1534/genetics.112.145730
2012
Sabatinos, S. A., Green, M. D., & Forsburg, S. L. (2012). Continued DNA Synthesis in Replication Checkpoint Mutants Leads to Fork Collapse. Molecular and Cellular Biology, 32(24), 4986–4997. https://doi.org/10.1128/MCB.01060-12
2010
Singh, S. K., Sabatinos, S., Forsburg, S., & Bastia, D. (2010). Regulation of replication termination by REB1 Protein-Mediated Action at a distance. Cell, 142(6), 868–878. https://doi.org/10.1016/j.cell.2010.08.013
Sabatinos, S. A. (2010). Recovering a stalled replication fork. Nature Educ, 3, 31.
Sabatinos, S. A. (2010). Replication fork stalling and the fork protection complex. Nature Education, 3(9), 40.
Sabatinos, S. A. & Forsburg, S. L. Molecular genetics of Schizosaccharomyces pombe. Methods Enzymol. 470, 759–795 (2010).
2009
Green, M.D., Sabatinos, S.A., Forsburg, S.L. (2009). Microscopy Techniques to Examine DNA Replication in Fission Yeast. In: Vengrova, S., Dalgaard, J. (eds) DNA Replication. Methods in Molecular Biology, vol 521. Humana Press. https://doi.org/10.1007/978-1-60327-815-7_26
Sabatinos, S.A., Forsburg, S.L. (2009). Measuring DNA Content by Flow Cytometry in Fission Yeast. In: Vengrova, S., Dalgaard, J. (eds) DNA Replication. Methods in Molecular Biology, vol 521. Humana Press. https://doi.org/10.1007/978-1-60327-815-7_25
2003
J.A. Wilson, S. Jayasena, A. Khvorova, S. Sabatinos, I.G. Rodrigue-Gervais, S. Arya, F. Sarangi, M. Harris-Brandts, S. Beaulieu, & C.D. Richardson, RNA interference blocks gene expression and RNA synthesis from hepatitis C replicons propagated in human liver cells, Proc. Natl. Acad. Sci. U.S.A. 100 (5) 2783-2788, https://doi.org/10.1073/pnas.252758799 (2003).
1999
Hsu EC, Sabatinos S, Hoedemaeker FJ, Rose DR, Richardson CD (1999) Use of site-specific mutagenesis and monoclonal antibodies to map regions of CD46 that interact with measles virus H protein. Virology 258: 314–326.
Sabatinos Lab 