ATR Expression in Pancreatic Cancer

Pancreatic cancer is one of the top leading causes of cancer deaths with only 10% of patients surviving for 5-years after diagnosis. Understanding what is contributing to the severity of pancreatic cancer and its persistence despite treatment is critical.
Ataxia telangiectasia and Rad3-related kinase (ATR) activity is linked with improved cell survival during chemotherapy, as it allows cells to escape the effects of induced replication stress.